Isosorbide Dinitrate (Isoket) is contraindicated in: known hypersensitivity to the active substance, to any of the excipients or to other nitrates or nitrites; low filling pressure; hypertrophic obstructive cardiomyopathy (HOCM); constructive pericarditis; cardiac tamponade; cardiogenic shock (unless some means of maintaining an adequate diastolic pressure is undertaken); circulatory collapse; aortic and/or mitral valve stenosis; severe hypotension (systolic blood pressure less than 90 mmHg); head trauma; cerebral hemorrhage; diseases associated with an increased intracranial pressure; marked anemia; hypovolemia; closed angle glaucoma; patients receiving phosphodiesterase-5 inhibitors (eg, sildenafil, tadalafil, vardenafil) (see Precautions; Interactions); patients receiving the soluble guanylate cyclase stimulator riociguat (see Interactions).
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